Louisville Rushes Past Boston College, 38-24

Saturday, October 25

LOUISVILLE, KY

7:30 p.m.

University of Louisville

6-1 , 3-1

Boston College

1-7 , 0-5

1st

2nd

3rd

4th

Boston College

Louisville

Photo by: Nicole Finch | Louisville Athletics

October 26, 2025 | Football

Box Score PDF Box Score Postgame Notes Jeff Brohm Postgame Press Conference Miller Moss Postgame Press Conference TJ Quinn & Kalib Perry Postgame Press Conference Keyjuan Brown & Mahamane Moussa Postgame Press Conference Photo Gallery

By: Erin Hughes

LOUISVILLE, Ky. - Running back Isaac Brown posted a career-high 205 rushing yards as the No. 19-ranked University of Louisville football team took down Boston College 38-24 on Saturday night inside L&N Federal Credit Union Stadium.

With the win, Louisville (6-1, 3-1 ACC) is now bowl eligible.

Quarterback Miller Moss went 15-of-27 for 187 yards including one passing touchdown and two rushing touchdowns. Moss tagged six receivers on the night, with Caullin Lacy leading the pack with 43 yards on six catches.

Isaac Brown had 14 carries on the night and rushed for one score, as Keyjuan Brown totaled a career-high 95 yards on 10 attempts and added one touchdown.

The UofL defense sacked BC quarterback Grayson James twice, both coming from Wesley Bailey. Six defenders combined for six tackles for loss, with Bailey logging two.

Louisville Head Coach Jeff Brohm said:
"Every victory is a good victory, so I'm proud of our team. One thing that I think stands out is that our guys play hard, even when things aren't super efficient and super smooth, we hang in there. We try to make adjustments, some of them work, some of them don't, but our guys responded. I don't think we had many plays in the first half, maybe 16 or so… our defense didn't start off great, they were able to move the ball up and down the field for two straight drives. And then I think we just picked up the pressure. You'd like to be a little more efficient in some base calls, but we were not, so the pressure package definitely helped us. That's been good, the ability to do that, we've used it quite a bit throughout the year, but I would like to be able to play some more normal defense, better and more efficient. So I think there are some things we can work through on offense. It was an up and down game, we made some big explosive plays and then we got stopped multiple times. Sometimes when teams are bringing the kitchen sink like, which they did at times, you're going to have negative plays, but when you get through that initial line, you've got to go score and we did. I just think that it's a good one to win, we've got a lot of things to learn, but our guys do play hard and they want to win, so I credit them for just sticking with it and coming out here and playing to the end."

How It Happened
First Quarter
06:36 – BC – Luca Lombardo capped the opening drive with a 38-yard field goal. 15 plays, 55 yards, 8:24. Boston College 3, Louisville 0
04:49 – UL – Miller Moss punched it in from 1-yard out for the touchdown. 3 plays, 75 yards, 1:47. Louisville 7, Boston College 3

Second Quarter
14:56 – BC – Grayson James found Lewis Bond in the end zone for a 6-yard score. 10 plays, 75 yards, 4:53. Boston College 10, Louisville 7
01:42 – UL – Miller Moss scrambled in untouched for a 9-yard touchdown. 5 plays, 56 yards, 1:10. Louisville 14, Boston College 10
01:02 – UL – Isaac Brown broke down the sideline for a 62-yard touchdown. 1 play, 62 yards, 0:09. Louisville 21, Boston College 10

Third Quarter
14:08 – BC – Grayson James and Kaelan Chudzinski connected for a 23-yard touchdown. 2 plays, 34 yards, 0:42. Louisville 21, Boston College 17
07:34 – UL – Caullin Lacy hauled in a 22-yard pass from Miller Moss for the score. 2 plays, 27 yards, 0:16. Louisville 28, Boston College 17

Fourth Quarter
08:13 – UL – Cooper Ranvier split the uprights from 41 yards. 4 plays, 7 yards, 2:21. Louisville 31, Boston College 17
06:17 – BC – Grayson James hit Jeremiah Franklin for a 21-yard touchdown. 8 plays, 68 yards, 1:48. Louisville 31, Boston College 24
01:49 – UL – Keyjuan Brown broke through the middle for a 67-yard touchdown. 5 plays, 83 yards, 1:10. Louisville 38, Boston College 24

Up Next
Louisville will hit the road to face Virginia Tech in Blacksburg, Va., at 3 p.m. ET on Saturday, Nov. 1. The game will be broadcast on The CW.