2021 Louisville Football Box Scores
| Date | Opponent | Location | Result | Stats |
|---|---|---|---|---|
| 09/06/21 | Ole Miss | Atlanta, Ga. | L, 24-43 | Box Score |
| 09/11/21 | Eastern Kentucky | Louisville, Ky. | W, 30-3 | Box Score |
| 09/17/21 | UCF | Louisville, Ky. | W, 42-35 | Box Score |
| 09/25/21 | Florida State | Tallahassee, Fla. | W, 31-23 | Box Score |
| 10/02/21 | Wake Forest | Winston-Salem, N.C. | L, 34-37 | Box Score |
| 10/09/21 | Virginia | Louisville, Ky. | L, 33-34 | Box Score |
| 10/23/21 | Boston College | Louisville, Ky. | W, 28-14 | Box Score |
| 10/30/21 | NC State | Raleigh, N.C. | L, 13-28 | Box Score |
| 11/06/21 | Clemson | Louisville, Ky. | L, 24-30 | Box Score |
| 11/13/21 | Syracuse | Louisville, Ky. | W, 41-3 | Box Score |
| 11/18/21 | Duke | Durham, N.C. | W, 62-22 | Box Score |
| 11/27/21 | Kentucky | Louisville, Ky. | L, 21-52 | Box Score |
| 12/28/21 | Air Force | Dallas, Texas | L, 28-31 | Box Score |
